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Early-phase clinical trials including a Phase 2 dose-ranging study published in the New England Journal of Medicine (2023) have demonstrated significant potential for weight reduction and metabolic improvement, generating considerable scientific interest

Transcriptomic analysis of brain mural cells in vivo shows low expression of SMA but high expression of NG2+ and PDGFR (Vanlandewijck et al., 2018)

While glucose is the preferred substrate for energy production in retinal neurons, under certain circumstances, including cell degeneration and glucose-deprived conditions, they use alternate fuel substrates in order to improve metabolic efficiency 9,10,11

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However, the antioxidant support it provides may gradually reduce if supplementation is discontinued